Chemical pathology clinical investigation and management of nephrolithiasis

ACP Best Practice No 181: Chemical pathology clinical investigation and management of nephrolithiasis.

Renal stones have afflicted humans for millennia but there is still no solution to this problem. This review discusses the laboratory and metabolic aspects of the clinical management of patients with renal stones, both primary and secondary in origin. First, non-pharmacological interventions such as increased fluid intake, decreased protein consumption, dietary changes in sodium, calcium, oxala...

A review of the heritability of idiopathic nephrolithiasis.

Familial aggregations of nephrolithiasis were already noted in the early 19th century and over the intervening years there has been gradual progression in classifying the familial forms of nephrolithiasis. To date, there are at least 10 different monogenic conditions where those affected have a predisposition to nephrolithiasis. However, all of these rare conditions probably account for less th...

The genetic basis of X-linked nephrolithiasis: leaving no stone unturned.

Knowledge to Practice Des Connaissances À La Pratique

Clinical question Is ultrasonography a safe and practical alternative to computed tomography for the initial investigation of suspected nephrolithiasis? Article chosen Smith-Bindman R, Aubin C, Bailitz J, et al. Ultrasonography versus computed tomography for suspected nephrolithiasis. N Engl J Med 2014;371(12):1100-10. Objective To assess the safety and efficacy of ultrasonography as a first-li...

Renal injury, nephrolithiasis and Nigella sativa: A mini review

Objective: The incidence and prevalence of kidney stone is increasing worldwide. After the first recurrence the risk of subsequent relapses is higher and the time period between relapses is shortened. Urinary stones can be severely painful and make a huge economic burden. The stone disease may increase the vulnerability of patients to other diseases such as renal failure. Medicinal herbs are ri...